Experimental Biology: Measurement and Analysis

microscope. While this chapter requires of its reader some knowledge of physics, it contains information which all electron microscopists should possess for a thorough understanding of the potentialities and limitations of this instrument. Three chapters follow on selected methods and techniques including preparation of metal specimens, mounting of particulate materials, and ultramicrotomy. The final section contains chapters on the applications of the electron microscope in physics, histology and cytology, bacteriology, and in the study of biological macromolecules. Each chapter is well written by an authority in his field. The illustrations are numerous and of excellent quality. References are well selected; the most recent are included and much of the older historical material are omitted. This volume presents a concise summary of the large number of methods and techniques being developed and the versatile applications of the electron microscope. While no one person can be an expert in all of the areas included in the book, the individual investigator should possess a broad perspective of the potential uses of the electron microscope. For this reason, this book will be of considerable value to the electron microscopist as it may suggest methods and techniques from other fields which may be applicable to his own particular area of research.